If you want accuracy and reliability with a variety of ammo, I would go with the Rugers, S&W Victory, or the Browning Buckmark. I have a 22/45 and a MKIII both with Volquartsen innards that will shoot right with my old Hammerli SP20 and 280's. The Ruger takedown is not a problem if you take the time to look at the factory website and follow the directions with respect to positioning the gun during re-assembly. I would gut the MKIII style mag disconnect and install Volguratsen parts. In fact I just bought a late model used 22/45, put the barrel assembly on a new Volquartsen alloy frame, and sold the factory polymer frame to another shooter Now I have a pea shooter that will run with the best of them.
Over the years working, I have observed all the "looks and feels like my MP, Sig, Walther, etc," in .22 caliber, all fall way short in their ability to be really dependable and accurate.
"Never pet a burning dog"