I've got one .380 experience to share. A few years back,I carried a Colt Mustang,with Silvertips. At a friend's house in the boonies,he had a mangy and hostile large breed dog that would wander into his yard and try to fight his lab. There were no neighbors for miles,so it must have been a dump off,wild dog.
I was over for a cookout and the dog came for a visit. My buddy wasn't a"gun guy" and had nothing to dispatch it with,and animal control wouldn't respond that far out. So I threw a pork chop around back to lure it away from the other guests,and confronted it. I got about 10 feet away and aimed,while he stooped down in a charge stance and snapped at me. I fired once,and saw blood trickle behind his ear,but he stood his ground and started barking at me.
Then I emptied the other 5 shots all into his front section,and his ran around the fence toward the other folks,barking! My friend charged him with a shovel that we were gonna bury him with,and BRAINED the damn animal.That stopped him.
I soon sold the gun and NEVER relied on anything smaller than a 9+P.
I currently carry a K40 with PDXs. Just my personal observation,YMMV....